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Lola Lotus Trial Option
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Lola Lotus Trial Option

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Lotus I is a randomized, multicenter controlled phase III clinical trial that provides evidence that oral dydrogesterone is as effective as current treatments in luteal phase support for women`Many clinical trials, including LOTUS, may offer some compensation for your time and effort as well as transportation costs and other costs related to trial participation. It doesn't cost anything to participate, and participants will not be charged for any procedure performed specifically as part of the trial. How do I know if I qualify?"The Ladies trial is split into two groups: the LOLA group comparing laparoscopic lavage with sigmoidectomy and the DIVA group comparing Hartmann's procedure with sigmoidectomy plus primary anastomosis. The DIVA section of this trial is still underway but here we report the results of the LOLA section.?Oral dydrogesterone has been used for luteal phase support on an empirical basis since the early days of in vitro fertilization (IVF) treatment. Systematic comparisons of oral dydrogesterone with vaginal progesterone, so far considered to be the standard of care, started to appear in the middle 2000s. Recently, a large, randomized, double-blind, double-dummy phase III trial on the use of daily@The LOTUS (Long-Term Usage of Esomeprazole vs Surgery for Treatment of Chronic GERD) trial compared maintenance therapy provided by esomeprazole (dose-adjusted when required) with standardized LARS in patients who responded well to acid-suppressive therapy. Herein, we report the final results of the 5-year follow-up for the LOTUS trial.%The Long-Term Usage of Esomeprazole vs Surgery for Treatment of Chronic GERD (LOTUS) trial compared a strategy of maintenance PPI therapy with laparoscopic anti-reflux surgery (LARS), and 5-year follow-up data have now been reported (JAMA 2011;305:1969-1977). This was a randomized, open, multicenter trial conducted in 11 European countries. Eligible patients were aged between 18 and 70 years~Clinical Trial NCT01850030 A Multicenter Study Comparing the Efficacy, Safety and Tolerability of Oral Dydrogesterone 30 mg Daily Versus Intravaginal Micronized Progesterone Capsules 600 mg Daily for Luteal Support in In-Vitro Fertilization (Lotus I)


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